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According to Pickart & Margolina's 2018 review, plasma GHK concentrations fall from approximately 200 ng/mL at age 20 to around 80 ng/mL by age 60 [16]

A: Rather than broadly inhibiting all MMPs, GHK-Cu research has documented selective effects: inhibitory activity toward MMP-1 (which degrades structural collagen) while stimulating MMP-9 (which facilitates cell migration and matrix clearing)

[DOI] [PubMed] [Google Scholar] Michelini E

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Anti-Aging & Collagen Support: Stimulates collagen production to improve skin elasticity, reducing the appearance of fine lines and wrinkles