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Inhibitor crizotinib is being administered to patients with uveal melanoma who are at high risk of recurrence in a phase II clinical trial, but the patient recruitment is ongoing and no results have been published ( There are several other inhibitors available for the inhibition of the c-Met signaling (Fig

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Glutathione is a tripeptide molecule synthesized within the body from three amino acids: cysteine, glycine, and glutamate

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Whilst the resulting fragment hits would be expected to bind with a weaker affinity than HTS hits due to their smaller size, they can show a comparatively better ligand efficiency 25