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On the other hand, beneficial metabolites such as butyrate can activate cellular mechanisms for protein clearance: butyrate readily crosses the BBB and can inhibit histone deacetylases, thereby activating gene expression programs that enhance autophagy and reduce toxic protein aggregates [55]

Its long-term safety and potential risks remain unknown, requiring further scientific investigation to determine a complete safety profile

P., Iaquinto, G., and Gluud, C