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Overexposure to selenium may cause irritation of the respiratory system, gastrointestinal tract, and eyes

Moreover, also a by-product of ethanol metabolism such as acetaldehyde, which is further oxidised to acetate by mitochondrial aldehyde dehydrogenase, seems to contribute primarily to the alcohol-induced liver diseases by acting at the genomic level through up-regulation of some redox-sensitive transcription factors involved in fibrogen-esis, such as AP-1 and NF-B

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It also modulates the permeability of gut which may facilitate neuroinflammation

A double-blind randomized trial of 5% ascorbic acid vs