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C96pAcF showed the lowest binding affinity, with a Kd value of 37.4 nM, 22.3 nM higher than that of the wild type, consistent with the Flex ddG calculation (Fig
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9 , e0003504 (2015)
This finding, and the unexpected observation of an increased risk of hyperactivity disorder among circumcised boys in non-Muslim families, need attention, particularly because data limitations most likely rendered our HR estimates conservative
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