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PMC 3204177

These receptors are highly expressed in the area postrema, nucleus tractus solitarius, and hypothalamus, brain regions critical for appetite regulation and energy homeostasis

Peptides like DSIP, Semax, and Oxytocin show potential in improving cognition, mood, sleep, sexual health, and treating neurodegenerative diseases.

doi: 10.1016/j.biopha.2021.111315 70 HotamisligilGS

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Repeated, systemic administration of ExerVs did not prevent skeletal muscle atrophy during disuse but inhibited collagen I accumulation during this critical phase