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The safety of PTMs is a crucial factor in determining their clinical application

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Maintenance dosing considerations: Community protocols commonly describe two maintenance approaches after the initial 8-12 week loading phase: (1) reduced frequency at the same dose (e.g., IV once monthly instead of weekly), or (2) transitioning from injectable/IV to high-bioavailability oral (liposomal) for convenience while accepting a modest reduction in peak levels

The Role of Phospholipids The fats used to create liposomes are often derived from sunflower or soy lecithin

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Boris M, Goldblatt A, Galanko J, James SJ (2004) Association of MTHFR gene variants with autism