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Correlation coefficient between serum HO-1 with any other clinical parameter (age, Charlson Comorbidity Index score [CCIS], partial pressure of oxygen in arterial blood/fraction of inspiratory oxygen [P/F ratio], serum Krebs von den Lungen [KL]-6) or with baseline HRCT parameters of ground-glass opacity (GGO) and honeycomb scores was low 23,24

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Blocking of NRP1/S-protein interaction with small-molecule inhibitors or monoclonal antibodies (mAbs) may reduce SARS-CoV-2 infectivity and provide potential intervention strategies for COVID-19 management 62

In this study, the 600 mg/day dose was as effective as the higher doses