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Researchers conduct most studies in preclinical settings, collect limited human data, and have not yet determined long-term systemic effects

10.1038/s41419-024-07166-8 6 Alexandre-SantosB.AlvesR.MatsuuraC.Sepulveda-FragosoV.VelascoL

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While B12 can be found in foods like meat, fish, and dairy, some people struggle to absorb enough through diet alone

[60] We observed an average 11 fold increase in the NR1D1 GP level at the end of 4 th week during 30-day intermittent fasting compared with the level before 30-day intermittent fasting