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Free heme is known to scavenge NO, potentially exacerbating the NO deficiency observed in G6PD-d and leading to vasoconstriction, increased vascular permeability, uptake of LDL, immune cell recruitment, and accelerated oxidation of LDL 60

The anti-inflammatory and metabolic effects of GLP-1 agonists could theoretically reduce cancer risk by lowering inflammation and improving metabolic parameters

Senescence-Associated Secretory Phenotype (SASP) and Senotherapy in Aging

Numerous studies have shown that patients with autoimmune inflammatory conditions have a decreased Treg/Th17 ratio, and that improving this ratio leads to both objective and subjective measures of improvement

The first 90 days are dose-finding

Some researchers report stable results up to 45 or 60 days, but 28 days is the window within which potency is most reliably maintained