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You drink, you pee, and you're still thirsty the loop is on and on

Perfect for combating dehydration caused by vigorous exercise, travel, illness, and pregnancy

PubMed Central, doi:10.1186/1746-1596-9-100

By inhibiting ion influx, CNQX may therefore counteract glutamate-mediated astroglial depolarization to maintain AQP4 in perivascular endfeet

We hypothesize that uncontrolled opening of glial hemichannels and pannexons may be a relevant downstream target that disturbs proper glia-to-neuron communication, affecting synaptic transmission in neural circuits crucial for alcohol rewarding

TrkB-T1 signaling in astrocytes also influences GABA uptake, calcium dynamics, and cell morphology [351355]