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Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets

This work was supported by the Shandong Province Medical and Health Science and Technology Program (202303060196)

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Their impact in the disease initiation and progression needs further investigation in vivo , but in general, these modifications in mutant ATXN3 were shown to modulate its stability, subcellular localization, enzymatic activity, neuroprotective function, self-assembly, its interaction affinity with molecular partners, and/or pathogenicity

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PMID: 41698066 J Immunother Cancer 2023 Feb;11(2):e005837