Yes, the human clinical trial evidence is lacking, but there is a silver lining emerging from years of self-experimentation
For IV use, typically thats done in a medical facility (hospital or infusion center)
This can cause some swelling and soreness in your arm
Choosing a muscle is dependent on the medication volume and the age or size of the patient
If you have symptoms like fatigue, brain fog, or nerve pain plus suboptimal B12 levels, a trial of supplementation is worth trying since it's very safe
GLP-1 agonists and tirzepatide achieve 1522% weight loss in clinical trials DSMES (Diabetes Self-Management Education and Support): ADA 2026 Recommendation 5.2 provide DSMES at diagnosis, annually, when complications develop, and at life transitions