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More recently, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RAs have transformed pharmacologic management by producing greater, more durable weight loss and meaningful cardiometabolic benefits

However, the suitability of current in vitro models, including those based on ARPE-19 cells, for accurately recapitulating RPE physiology in the context of diabetes warrants further optimization

H.PapageorgiouC.et al (2021)

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