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The lack of ATP collapses the vesicular proton gradient, forcing stored catecholamines to leak out of the vesicles and flood the axoplasm/cytoplasm of the nerve terminal (Silver et al., 2001)

Case in point, 7 days of L-citrulline supplementation at a daily dose of 6 g significantly increase plasma citrulline, arginine, and nitrite levels, VO 2 kinetics, in response to moderate intensity (70% VO 2 peak) exercise performance [18]

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