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Method Angiogenesis plays a major role in the process of neovascularization, so angiogenesis is a potential target for wound healing as the newer blood vessels formed over the injured surface are important to provide nutrients, immune cells, and oxygen for the healing of wounds

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The process in turn activates other transcription factors (TFs) such as Nuclear factor NF-kappa-B (NFKB1), Nuclear factor erythroid 2-related factor 2 (NRF2), and Transcription factor Sp1, also known as specificity protein 1 (SPI)

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