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Space them by at least two hours or use on alternating days during the adjustment period

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The genetic association between the genes encoding methionine synthase and N5,10-methylenetetrahydrofolate reductase suggests a close relationship between these enzymes and the tetrahydrofolate metabolism (Figure 2) [14, 15, 16, 17]

Therefore, GSH itself may not be effective at direct reduction of reactive oxygen species under physiological conditions

Townsend DM, Manevich Y, He L et al (2008) Novel role for glutathione S-transferase