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Route of administration, as well as age, liver function and potential drug interactions (since melatonin is metabolized in the liver), may influence plasma melatonin levels and should be taken into account (115)

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Extensive research has shown that changes in lipid profiles, especially increased TGs and reduced high-density lipoprotein cholesterol (HDL-C), correlate with greater risk and heightened severity of depression (11, 12)

According to the three-dimensional structure of Cu/Zn-SOD, the active site of SOD is a "hydrophobic pocket" centered on Cu