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Glossary AD Alzheimers disease ALK2 Activin receptor-like kinase-2 APP Amyloid Precursor Protein ASDs Atrial septal defects ATP adenosine triphosphate ATG autophagy-related genes AUST2 Autism susceptibility candidate 2 gene AVSDs Atrioventricular septal defects BACE2 Beta-Secretase 2 CAT Catalase CHDs Congenital heart defects CNV Copy number variants COL6A Collagen Type VI Alpha 1 Chain CRELD1 Cysteine Rich With EGF Like Domains 1 DRP1 Dynamin-1-Like Protein DS Down Syndrome DSCAM Down Syndrome Cell Adhesion Molecule DSCR1 Down Syndrome Critical Region-1 DYRK1A Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A E2f E2F transcription factor 1 ENG Endoglin, a TGF-beta binding protein of endothelial cells ESCs Embryonic stem cells EZH2 Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit FLNA Filamin A GATA3 GATA binding protein 3 GRK2 G-protein-coupled receptor kinase 2 GPX Glutathione Peroxidase Hsa21 Human chromosome 21 HEY2 Hairy/enhancer-of-split related with YRPW motif protein 2 I/R ischemia/reperfusion IL10RB Interleukin 10 receptor subunit beta IFNAR IFN alpha/beta receptor IFNGR Interferon-gamma receptor iPSC induced Pluripotent Stem Cells KCNH2 Potassium Voltage-Gated Channel Subfamily H Member 2 KCNJ6 Potassium Inwardly Rectifying Channel Subfamily J Member 6 KIAA2022 NEXMIF-neurite extension and migration factor lncRNAs long non-coding RNAs MEF2C Myocyte enhancer factor 2C miRNAs micro-RNAs mTOR mammalian Target of Rapamycin NFAT Nuclear factor of activated T-cells ncRNAs non-coding RNAs NKX2.5 NK2 Homeobox 5 OCR Oxygen consumption rate p62 SQSTM1 (Sequestosome 1)/ubiquitin-binding protein p62 PAH Pulmonary arterial hypertension PLAC4 Placenta-specific protein 4 PINK1 PTEN-induced kinase 1 PPP2R2B Protein Phosphatase 2 Regulatory Subunit Bbeta Rb Retinoblastoma protein (pRb) RCAN1 Regulator of Calcineurin 1 RIPK4 Receptor Interacting Serine/Threonine Kinase 4 ROS Reactive oxygen species SMARCA5 SJQ/SMB-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 SNP Single polymorphism SOD1 Superoxide dismutase (Cu-Zn) type 1 SRSF6 Serine/arginine-rich splicing factor 6 tbx2b tbx2b T-box transcription factor 2b (zebrafish) TBX5 T-box transcription factor 5 T2D Type 2 diabetes TNNI3 Troponin I3, cardiac type TNNT2 Troponin T2, cardiac type VEGFA Vascular Endothelial Growth Factor A VSDs Ventricular septal defects ZBTB21 Zinc Finger and BTB Domain Containing 21 References 1 AlharbiK

Int J Adolesc Med Health 33(6):339345 Zhang B, Wang HE, Bai YM, Tsai SJ, Su TP, Chen TJ et al (2020) Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

Research suggests that individuals with lupus may have lower levels of glutathione, which can contribute to the oxidative stress and inflammation commonly observed in the disease

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However, as seen previously for HCV, the genotype affects the induced pathway