Current Pharmaceutical Design, 19(1), 7683
Wounds take longer to close, injuries persist longer, recovery from exercise slows, and tissue quality gradually decreases
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When an active subcomponent (SCS) in the leaves of the traditional medicinal plant flowering shrub ( Strobilanthes crispa (L.) Blume) in Malaysia and Indonesia used in combination with TAM under low doses of antiestrogens, it has been reported to synergistically induce cell cycle arrest in MCF-7 and MDA-MB-23 in the G1 phase, via mechanisms involving the regulation of cyclin D1, p21 CDK inhibitor and p53 tumor suppressor protein, modulation of mitochondrial membrane potential, and activation of caspase-8 and caspase-9 (Yaacob et al., 2014)
