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For legitimate laboratories, it is generally available under research use only terms

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Overall preclinical safety profile has not raised major flags at tested doses

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Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess

It may cause symptoms related to neurological failure like loss of feeling or sensation, irregular bowel movements, sleep disorder, getting irritated, feeling depressed, memory loss, Alzheimer's disease