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10.1056/NEJMra2200923 80 LuoS.AiY.XiaoS.WangB.WangY

Forkhead Box O3 (FOXO3), an important transcription factor, reduces lipid peroxidation and intracellular iron accumulation by upregulating antioxidant genes and inhibiting the NF-B/MAPK signaling pathway, thereby lessening chondrocyte ferroptosis and ECM degradation (Zhao et al., 2023)

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