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If youre smoking, dehydrated, overexposed to the sun, or eating junk food like its your birthday every day, youre basically making glutathiones job harder

7 Lessening Chemotherapy Side Effects Prevention and mitigation of chemotherapy side effects can avert the need to interrupt or stop treatment and allow for more aggressive dosing schedules, thus increasing the chance of treatment success

Also of note: an important and necessary trace mineral selenium is essential to cells and acts as a component of glutathione peroxidase

Effect of Omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) supplementation on cognition in children and adolescents: A systematic literature review with a focus on n-3 LCPUFA blood values and dose of DHA and EPA

(PubMed) Obrosova IG

Only if it is reduced, meaning it contains the extra electrons, can glutathione effectively function as an antioxidant