Glycyrrhizin inhibits the metabolism of diosbulbin B (Yang et al., 2024), promotes bile acid efflux by increasing the expression of Nrf2/Farnesoid X Receptor- Bile Salt Export Pump (FXR-BSEP)/Multidrug Resistance-Associated Protein (MRP)2/P-glycoprotein/UDP-glucuronosyltransferase 1A1(UGT1A1), modulates gut microbiota, alleviates inflammation and oxidative stress, and improves diosbulbin B-induced liver injury (Wang et al., 2025)
Preclinical studies demonstrated that pretreatment with 2-deoxyglucose (2-DG) induced autophagy and restricted the growth of M
Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro
The parallels with caffeine and paraxanthine highlight the potential of 1-MX to confer similar neuroprotective and cognitive benefits, supporting its novelty to enhance cognition
its a systemic autoimmune disease
Bioinformatic analyses suggest GHK-Cu can modulate expression of 4,000+ human genes relevant to tissue repair and aging