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In conclusion, the pathological features and pathogenic factors of PD include the excessive accumulation of -Syn in the substantia nigra pars compacta or its gene mutation

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doi: 10.1111/nbu.12278 579 GormazJGVallsNSotomayorCTurnerTRodrigoR

We postulate that NAD + /NADH disequilibrium in the gdh3 / gdh3 mutant led to a different proline catabolism in the mutant compared to the wild-type strain