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BC in the treatment of IS is associated with steroid hormone biosynthesis, metabolic pathways, and neuroactive ligand-receptor interactions ( 2) Conduct larger-scale and more standardized pharmacological experiments and clinical trials to actively evaluate the efficacy and safety of BC in IS treatment

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L-Glutamine can be administered as: Powder mixed with food Capsules (if suitable for dogs size) Liquid supplements Soft chew supplements Mixed with bone broth Conclusion L-Glutamine is a valuable supplement for supporting canine health, particularly in areas of digestive function, immune support, and recovery

Lactobacillus paracasei Jlus66, isolated from natural fermented milk, also has great potential in preventing NAFLD (Ye et al., 2017), which was consistent with that of Wang et al (Wang et al., 2019)