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The role of OS in ALS pathology, whether as a primary cause of disease or a secondary consequence, is now well recognized and many preclinical and clinical studies have consistently demonstrated that the disease is characterized by high levels of OS markers able to induce cellular damage, impaired cell signalling, and finally cell death [25, 86]

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A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats

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The fractured H 1 probe initialized the hybridization with H 2 and generated a single-stranded tail in H 2 , which might dissociate or enhance the mobility of H 2 on the surface of cores, benefiting its hybridization with H 3 and renewing a single strand tail in H 3

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The designation does not permit personal usebuyers must represent research institutions and provide documentation verifying research intent

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Children aged 4 and older may be considered in specific medical situations, while teenagers and adults should follow age-appropriate dosing guidance to ensure safety and efficacy

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