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Studies indicate that exposure to PS-NPs significantly downregulates dopamine levels in zebrafish (Ren et al., 2024), mechanistically linked to MPs-triggered neuroinflammation that inhibits tyrosine hydroxylase, a key enzyme in dopamine synthesis (Wang et al., 2025)

In 1954 by Pinsent was established with the beneficial effect of selenium for living organisms the discovery that certain bacteria grew faster in selenium fortified medium [8]

The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect

Endocrine control of body composition in infancy, childhood, and puberty

concurrently, it coordinately upregulates GPX4 expression, enhances GSH synthesis, and modulates iron metabolism proteins to effectively inhibit neuronal ferroptosis (248, 249)

As a first approximation, we consider hydrogen bonds and hydrophobic contacts as the only significant contributors to the binding energy