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PUFA-PE production depends on coordinated action between acyl coenzyme A synthetase long-chain family member 4 (ACSL4) and lysophospholipid acyltransferase 3 (LPCAT3), which collectively activate and incorporate PUFAs (e.g., docosahexaenoic acid, arachidonic acid) into membrane lipids (43)
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Additionally, by feeding into the GABA shunt, it helps to calm neuroinflammatory hyperarousal, supporting a more stable, positive mood and emotional resilience
Characterization of tau binding by gosuranemab
Western blotting HCT116 cells were seeded in a six-well plate and treated with GSTO1 inhibitors for 24 h