Real-time PCR was performed using the TB Green Premix Ex Taq II kit (RR820A, Takara, Japan) following the manufacturers protocol
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Irreversible aggregates do not revert back to their monomeric forms and can be caused by the rearrangement of disulfide bonds or the formation of new structures due to hydrophobic association
Its activity may presumably be exerted by chelating iron (Kitazawa et al., 2005)
Clinical translational research shows that in a Phase II clinical trial of newly diagnosed high-risk diffuse large B-cell lymphoma (DLBCL) (n=100), oral HDAC inhibitor Tucidinostat (20 mg per dose) in combination with the R-CHOP regimen achieved an 86% complete response rate (91)
However, whether supplementing glutathione corrects this imbalance or produces clinical benefit has not been definitively established in rigorous randomized controlled trials
