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Dornase /DNase Ibased NET degradation strategies: By enzymatically digesting extracellular chromatin webs, DNase approaches reduce NETmediated tissue damage and thrombosis in experimental settings [96]

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The subsequent antigen presentation triggers the activation of Th1 and Th17 cells, leading to the release of pro-inflammatory cytokines (IL-2, TNF-, IFN-, IL-17), which in turn amplify oxidative stress and perpetuate an amplifying loop of inflammation and tissue damage (Kubiak et al

When you see a dose range cited in research literature, treat it as a description of what a specific trial protocol tested not a instruction to replicate without independent verification of your own protocol and research context

In a developmental toxicity study, the maternal no-observed-adverse-effect level (NOAEL) was 250 mg/kg per day, while the developmental NOAEL was 500 mg/kg daily

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