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Neither is "better" in a research sense, because the two are studied for different mechanistic questions

Arias E, Rostron BL, Tejada-Vera B (2010) United States life tables, 2005

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In particular, it can reprogram the tumor microenvironment, converting it from a noninflamed cold tumor to an inflamed hot tumor

Even fundamental optical phenomena such as up-conversion and down-conversion fluorescence remain incompletely understood and inconsistently measured, limiting meaningful comparisons across studies [167]

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