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Data are from in vitro and in vivo (cell and animal) studies and cannot be extrapolated to humans .

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Tissues were fixed with 4% formaldehyde, embedded in paraffin, and 7 m sections were taken

Furthermore, CHAC2 also maintains pluripotency through a CHAC1-independent pathway by regulating the NRF2-GCL axis, thereby sustaining GSH biosynthesis and concurrently suppressing ROS production (Wang et al., 2017)