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At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S -transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta

Discussion In this paper, we develop the first mathematical model of the GSH antioxidant system in the outer retina, capturing the most essential components for ROS creation, GSH production, oxidation in neutralizing ROS, and reduction as well as the diversion of glucose into the PPP to synthesize NADPH

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