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Beyond synthesis, the compounds were investigated using residue-specific chemoproteomics, enabling deeper insight into their antibacterial properties and helping to explore structureactivity relationships within this class of natural product derivatives

PMID: [25415472] REFERENCES National Center for Biotechnology Information

Gut 63 (5), 727735

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Ito et al., 2023) (this may be particularly relevant for the destabilization of myelin), synaptic dysfunction (Tu et al., 2014) (this includes impairment of signaling at the axo-myelinic synapse, crucial for survival of the myelinated axon

Except for orforglipron, incretin-based drugs appeared to increase HDL-cholesterol up to approximately 13% with pooled tirzepatide doses