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Nausea and constipation show up, usually mild and usually fading with a slow ramp

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Across preclinical research, BPC-157 has been reported to have a favorable tolerability profile: a 2021 Frontiers in Pharmacology review noted no reported toxicity in animal studies, with the LD1 (lethal dose for 1% of animals) not reached

Moreover, the gene expression profile of antioxidant enzymes showed a significant increase in SOD and CAT via the dermal route and GR and GPx via the subcutaneous route [99]

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