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Additionally, antimicrobial peptides in general have some remarkable disadvantages that are described here briefly together with some selected successful clinical trials made with antimicrobial peptides of vertebrates

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Mechanistically, the literature often points to pathways tied to: angiogenesis and vascular signaling (VEGF-related pathways), nitric oxide signaling, and cell migration / fibroblast activity involved in tissue remodeling

It also modulates nitric oxide pathways and growth factor signaling, supporting gut mucosal integrity and reducing systemic inflammation

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