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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

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10.1007/s12602-024-10396-z 23 DeaneC.KellyO.OMorainC

What matters is the resulting concentration: extremely dilute solutions (under ~0.5 mg/mL) require larger injection volumes per dose, which becomes uncomfortable and can shift absorption kinetics

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