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This molecule is known to cause free radical production in neutrophils, smooth muscle cells in the vessels and endothelium

Edward Rubin, MD board-certified in Pain Medicine and Anesthesiology, with fellowship training at Cornell, Columbia, Hospital for Special Surgery, and Memorial Sloan Kettering

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Current limitations include the complexity of the mechanisms of action, which makes it difficult to identify predictive biomarkers of response, the lack of detailed pharmacokinetic data for synthetic TB-500, and the difficulty of translating effective doses from animal models to humans

[DOI] [PubMed] [Google Scholar] [103].Cardiel MH, Tumlin JA, Furie RA

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