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Upon further history taking, the patient had a history of gout arthritis and allopurinol use

Uversky VN, Oldfield CJ, Dunker AK (2008) Intrinsically disordered proteins in human diseases: introducing the D 2 concept

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This process can send the cell into a downward tailspin, whereby the cell is even more susceptible to free radical stress, and eventually, this process can end up creating a runaway neurotransmitter response