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Because heparin is a HS variant with increased degrees of sulfation and negative charge (Figure 2C), our findings support that the bulk of free energy (G) of the interaction is derived from the entropically favorable displacement of cations from HS upon Hh binding ( FIGURE 2 (B) HS mixtures derived from 2 independent pools of mouse embryos were coupled to FPLC columns and Shh binding to these matrices analyzed

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Results To assess toxicity of APAP to HepG2 cells, we carried out a high-dose short-exposure experiment

Helps prevent drug resistance

Kizhakke, P

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