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Stress-responsive transcription factors Stress-responsive transcription factors, including p53, nuclear factor erythroid 2related factor 2 (Nrf2), FOXOs, activating transcription factors ( ATFs), and hypoxia-inducible factor-1 (HIF-1), mediate cellular responses to diverse stressors, such as DNA damage, oxidative stress, hypoxia, ER stress, and metabolic imbalance

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In Phase II metabolism, toxic doses of paracetamol can also be metabolized by conjugation with cysteine and mercapturic acid, forming additional safe metabolites that can be excreted from the body