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These medications reduce gastric acid production, which is necessary for releasing dietary vitamin B12 from food proteins and for maintaining the stability of the B12-intrinsic factor complex

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Reducing the NNMT expression impairs the cell proliferation and tumor growth of mesenchymal glioblastoma stem cells (GSCs), accompanied by reduced methylation ability

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In the steady state there is no anemia, no evidence of increased red cell destruction, nor alteration in blood morphology