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On the other hand, Th17 cells and IL-17 present in the skin activate a nearby inflammatory response mediated by neutrophils, which ultimately results in damage to the tissue (122, 123)

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As such, conducting this test in non-classic cases of SPIGFD can result in prolonged and unnecessary investigations, associated with significant economic and resource burden on healthcare services [39]

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Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone secretory bursts