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Concluding remarks The levels and compartmentalization of NAD + dictate energy state that impinges on normal physiological and biological responses, as indicated by the regulatory role of NAD + in proper redox homeostasis, genomic stability, gene expression, circadian clock, inflammation, metabolism, cellular bioenergetics, mitochondrial homeostasis and adaptive stress responses

Electron microscopy was not applied in the study due to the long post-mortem period

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auris , with a well-documented safety profile (Thompson et al., 2024b)

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