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SSAO activity is significantly increased in diabetic patients, which can lead to increased production of toxic metabolites such as formaldehyde [48]

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Existing human data on IGF-1 peptides largely involves mecasermin (native rhIGF-1) for IGF-1 deficiency, not the LR3 analog used in research contexts

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But periodic breaks and regular health monitoring are recommended to assess ongoing benefits and prevent potential tolerance development