While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition
Antioxidant oxidative stress, and degenerative neurological disorders
The agency has flagged it among bulk substances it sees as safety risks for compounding, and its status is shifting: a federal compounding advisory review is set for July 2026 to weigh whether licensed pharmacies can prepare it
These injections are commonly used to address areas of stubborn fat and can complement other weight loss strategies while helping increase energy levels
Its best-documented effect is a meaningful reduction of visceral adipose tissue the deep abdominal fat in people with HIV-associated lipodystrophy, alongside improved lipid profiles, over roughly 612 months of daily use [3] [4]
It mustnotbe used in newborns or for inhalation