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The C-terminal amide protects against carboxypeptidase degradation, the -aminoisobutyric acid (Aib) at the N-terminus blocks aminopeptidase cleavage, and the two non-natural D-amino acids (D-2Nal and D-Phe) confer selectivity for the GHS-R over related receptors

3 Methods 3.1 Literature search We conducted a comprehensive search on the PubMed (www.pubmed.com) and Web of Science (www.webofscience.com) databases for articles on procyanidins and diabetes published from 1 January 2000, to 30 December 2024

doi: 10.3390/ijms26157520 59 Marsol-VallA.AittaE.GuoZ.YangB

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