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Protein glycation is thus responsible for the development of inflammation, but it also disrupts extracellular matrix remodeling and intercellular signaling 77,78

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ROS including superoxide (O 2 ), hydroxyl radical (HO ), and hydrogen peroxide (H 2 O 2 ) may cause lipid peroxidation, cell membrane damage, inflammation, and autoimmune diseases (Figure 1)

doi:10.1016/j.abb.2006.01.013 Ding Y, Choi KJ, Kim JH, Han X, Piao Y, Jeong JH, Choe W, Kang I, Ha J, Forman HJ, Lee J, Yoon KS, Kim SS (2008) Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation

Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction