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Footnotes Check the online version for the most updated information on this article, online supplements, and information on authorship & disclosures: www.haematologica.org/content/103/9/1493 Received December 18, 2017

High levels of molecular oxygen and iron (found in the heam group of Hb) in RBCs create the potential for the formation of ROS

Oxidative stress in an assisted reproductive techniques setting

To neutralize ROS, cells induce various antioxidant systems, including the activation of the protein machinery that produces glutathione [10], the most abundant antioxidant scavenger in all cells [11, 12]

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